Metoprolol tartrate Containing Glutaraldehyde Cross-linked Chitosan- Polyvinyl pyrrolidone Matrix Transdermal Patch: Preparation and Characterization
نویسنده
چکیده
The present study was undertaken to develop a suitable transdermal matrix patch of Metoprolol tartrate with different proportions of polyvinyl pyrrolidone (PVP) and chitosan crosslinked with glutaraldehyde (GA). The prepared transdermal patches were subjected to different physicochemical evaluations such as thickness, tensile strength, folding endurance, drug content, swellability, surface pH, water vapour transmission, in vitro permeation and skin irritation studies. The permeability of drug was increased with increase in PVP content. The in vitro drug permeation followed Korsmeyer-Peppas model with non-Fickian diffusion mechanism. The patches were found to be free of any skin irritation.
منابع مشابه
Matrix type transdermal drug delivery systems of metoprolol tartrate: in vitro characterization.
The monolithic matrix type transdermal drug delivery system of metoprolol tartrate were prepared by the film casting on a mercury substrate and characterised in vitro by drug release studies, skin permeation studies and drug-excipients interaction analysis. Four formulations were developed, which differed in the ratio of matrix-forming polymers. Formulations MT-1, MT-2, MT-3 and MT-4 were compo...
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